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KMID : 0613820090190101489
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Journal of Life Science
2009 Volume.19 No. 10 p.1489 ~ p.1494
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The Effect of Swimming and Minocycline on Motor Function and Expression of Bcl-2 after Spinal Cord Injury in the Rats
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Ha Mi-Sook
Ha Bae-Jin
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Abstract
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This study was designed to investigate the effects of swimming and minocycline on motor function recovery and Bcl-2 expression after spinal cord injury (SCI) in rats. After operation, neurological motor behavior test (BBB scale) on days 1, 4, 7, 10, and 14 were tested. Western blot and immunohistochemical assessment (Bcl-2) were performed on day 14. BBB scale started to show a statistically significant difference on day 7 (p＜0.05). On day 14, it showed the most significant (p＜0.05) difference. Expression of Bcl-2 increased in all the experimental groups. In particular, the highest expression of Bcl-2 appeared in the swimming and minocycline groups. Based on these results, minocycline and swimming were the most effective factors in the motor behavior function and immunohistochemical assessment of SCI rats.
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KEYWORD
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Spinal cord injury, swimming, minocycline, Bcl-2
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